contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms
نویسندگان
چکیده
Juan Sanchez-Esteban, Yulian Wang, Edward J. Filardo, Lewis P. Rubin, and Donald E. Ingber Division of Neonatology, Department of Pediatrics, Women and Infants Hospital of Rhode Island; Division of Hematology and Oncology, Department of Medicine, Rhode Island Hospital, Brown Medical School, Providence, Rhode Island; and Vascular Biology Program, Departments of Pathology and Surgery, Children’s Hospital, Harvard Medical School, Boston, Massachusetts
منابع مشابه
Integrins beta1, alpha6, and alpha3 contribute to mechanical strain-induced differentiation of fetal lung type II epithelial cells via distinct mechanisms.
Mechanical forces regulate lung maturation in the fetus by promoting type II epithelial differentiation. However, the cell surface receptors that transduce these mechanical cues into cellular responses remain largely unknown. When distal lung type II epithelial cells isolated from embryonic day 19 rat fetuses were cultured on flexible plates coated with laminin, fibronectin, vitronectin, collag...
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Mechanical forces generated in utero by repetitive breathing-like movements and by fluid distension are critical for normal lung development. A key component of lung development is the differentiation of alveolar type II epithelial cells, the major source of pulmonary surfactant. These cells also participate in fluid homeostasis in the alveolar lumen, host defense, and injury repair. In additio...
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Mechanical forces are important for fetal alveolar epithelial cell differentiation. However, the signal transduction pathways regulating this process remain largely unknown. Based on the importance of the extracellular-regulated protein kinase (ERK) pathway in cell differentiation, we hypothesized that this cascade mediates stretch-induced fetal type II cell differentiation. We demonstrate that...
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